Boise State started the season with a 126-49 win against Life Pacific at ExtraMile Arena.
The 126 points are the most in program history, breaking a nearly-50-year-old record, and the 77-point margin of victory set an all-time mark.
The Broncos used a 30-0 run early in the first half to seize control of the game, eventually taking a 69-23 lead into halftime.
Boise State broke the previous record of 118 set in 1971, against Portland State.
The Broncos will hit the road for the first time this season on Saturday, at No. 15 Oregon.